منابع مشابه
Selected Reading Shedding Uv Light on the Phase Problem
viously very valuable information for structure-based inhibitor design studies. The three-dimensional structure reveals that membrane binding is mediated by a 30 amino acid segment, consisting of two short a helices whose axes are predicted to be approximately parallel to and embedded in the membrane lipid bilayer. Comparison with the structure of the homologous carnitine acetyltransferase (Jog...
متن کاملShedding UV Light on Alternative Splicing
After DNA damage, cells modulate pre-messenger RNA (pre-mRNA) splicing to induce an anti- or proapoptotic response. In this issue, Muñoz et al. (2009) uncover a cotranscriptional mechanism for activating alternative pre-mRNA splicing after ultraviolet irradiation that depends unexpectedly on hyperphosphorylation of the RNA polymerase II C-terminal domain and decreased rates of transcription elo...
متن کاملShedding “UV” Light on Endogenous Opioid Dependence
Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and produces an endogenous opioid-dependent state.
متن کاملShedding light on an underground problem.
I this issue of PNAS, Nishimura et al. demonstrate that ASTRAY, the legume homolog of HY5, a transcription factor that mediates light signaling and photomorphogenesis above ground, also affects the interaction between legume roots and their rhizobial endosymbionts underground (1). At first glance, this is a confusing result. What is a transcription factor that mediates light signaling doing reg...
متن کاملShedding Light on Light*
There are four books describing early studies and views on light, optics and vision that are considered to be landmarks in this branch of science. The first of these is Euclid’s Optica, published about 300BC, in which he postulated that light travelled in straight lines; he described the laws of reflection and described them mathematically. The second is by Ptolemy. He is best known for his 15 ...
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ژورنال
عنوان ژورنال: Structure
سال: 2006
ISSN: 0969-2126
DOI: 10.1016/j.str.2006.03.004